Computational modeling of cardiac fibroblasts and fibrosis
نویسندگان
چکیده
منابع مشابه
The origin of fibroblasts and mechanism of cardiac fibrosis.
Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can deriv...
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Metastasis-associated protein, S100A4 is suggested as a marker for fibrosis in several organs. It also modulates DNA binding of p53 and affects its function. However, the functional role of S100A4 in the myocardium has remained unclear. Therefore, we investigated the role of S100A4 and its relationship with p53 in cardiac fibrosis. In Dahl-rat hypertensive heart disease model, S100A4 was upregu...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2016
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2015.11.020